<p>ISO 21427-2:2006 specifies a method for the determination of genotoxicity of water and waste water using a mammalian <i>in vitro</i> test which detects damage, induced by water-soluble substances, to the chromosomes or the mitotic apparatus of V79 cells from the Chinese hamster.</p>
<p>The micronucleus test allows the identification of substances that cause cytogenetic damage which results in the formation of micronuclei containing lagging chromosome fragments and/or whole chromosomes.</p>
<p>The assay is based on the increase in the frequency of micronucleated cells after incubation with and without metabolic activation.</p>
Registration number (WIID)
39681
Scope
<p>ISO 21427-2:2006 specifies a method for the determination of genotoxicity of water and waste water using a mammalian <i>in vitro</i> test which detects damage, induced by water-soluble substances, to the chromosomes or the mitotic apparatus of V79 cells from the Chinese hamster.</p>
<p>The micronucleus test allows the identification of substances that cause cytogenetic damage which results in the formation of micronuclei containing lagging chromosome fragments and/or whole chromosomes.</p>
<p>The assay is based on the increase in the frequency of micronucleated cells after incubation with and without metabolic activation.</p>
