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Hydroquinone has been longer used in cosmetic products for skin whitening and depigmentation of dermal spots or imperfections. Due to its cytotoxic effects, its use has been regulated by the Directive 76/768/EC Appendix-III "List of substances that cosmetic products must not contain except restrictions and conditions laid down" and the Directive 2008/88/EC amending Directive 76/768/EEC. Nowadays, its use is prohibited in all cosmetics including as colouring agent for oxidative hair dyes. The Hydroquinone is only permitted in artificial nail with a limit fixed at 0.02% (after mixing for use). From the 11 of July 2013, hydroquinone will be regulated by the regulation 1223/2009 that will replace the directive 76/768/EC.
Depigmentation is a side effect of topical steroids, in this way corticosteroids might be used as whitening agents in topic medical preparations. Corticosteroids are registered in the list I of Poisons (6 Art.L.5132-CSP) and in the Directive 76/768/EC (entry 300) Appendix II "List of substances that can not enter the composition of cosmetic products", and as such their use is prohibited in cosmetic products. Corticoids can only be used in drugs after been approved by an official regulator. Nevertheless, recent market surveys have shown that some corticosteroids could be present in some products marketed as cosmetics in the EU.
The cosmetic directive "95/32/EC (Identification and determination of hydroquinone in cosmetics)" gives an analytical method for the assay of
hydroquinone and its ethers in cosmetic products for whitening the skin. In order to update and extend this official method to the identification and assay of some corticosteroids in skin whitening cosmetic products, this standard describes an HPLC/UV method for the assay of hydroquinone, ethers of hydroquinone and at least 3 corticosteroids frequently found in skin whitening cosmetic products: Clobetasol propionate, Betamethasone dipropionate, Fluocinonide. Furthermore information on qualitative determination of additional corticosteroids possibly found in cosmetics would be given in the annex.
Reģistrācijas numurs (WIID)
41366
Darbības sfēra
Hydroquinone has been longer used in cosmetic products for skin whitening and depigmentation of dermal spots or imperfections. Due to its cytotoxic effects, its use has been regulated by the Directive 76/768/EC Appendix-III "List of substances that cosmetic products must not contain except restrictions and conditions laid down" and the Directive 2008/88/EC amending Directive 76/768/EEC. Nowadays, its use is prohibited in all cosmetics including as colouring agent for oxidative hair dyes. The Hydroquinone is only permitted in artificial nail with a limit fixed at 0.02% (after mixing for use). From the 11 of July 2013, hydroquinone will be regulated by the regulation 1223/2009 that will replace the directive 76/768/EC.
Depigmentation is a side effect of topical steroids, in this way corticosteroids might be used as whitening agents in topic medical preparations. Corticosteroids are registered in the list I of Poisons (6 Art.L.5132-CSP) and in the Directive 76/768/EC (entry 300) Appendix II "List of substances that can not enter the composition of cosmetic products", and as such their use is prohibited in cosmetic products. Corticoids can only be used in drugs after been approved by an official regulator. Nevertheless, recent market surveys have shown that some corticosteroids could be present in some products marketed as cosmetics in the EU.
The cosmetic directive "95/32/EC (Identification and determination of hydroquinone in cosmetics)" gives an analytical method for the assay of
hydroquinone and its ethers in cosmetic products for whitening the skin. In order to update and extend this official method to the identification and assay of some corticosteroids in skin whitening cosmetic products, this standard describes an HPLC/UV method for the assay of hydroquinone, ethers of hydroquinone and at least 3 corticosteroids frequently found in skin whitening cosmetic products: Clobetasol propionate, Betamethasone dipropionate, Fluocinonide. Furthermore information on qualitative determination of additional corticosteroids possibly found in cosmetics would be given in the annex.
